It’s over … again.

Jude Law and Sienna Miller have ended their relationship, the actor’s rep confirms to UsMagazine.com.

This isn’t the first time the couple has experienced heartbreak. After two years of dating, they split in 2006 when Law, now 38, admitted he had cheated on Miller with his children’s nanny. (He has two sons and a daughter with his ex-wife, actress Sadie Frost, 45.)

“That was a very pivotal time in my life, and I’m happy saying that,” Miller, now 29, told Vogue in July 2009. “It’s a private moment when you get your heart broken for the first time, and that was the absolute antithesis of private. It couldn’t have been more public!”

Law and Miller reconciled in late 2009; they even hit the red carpet together at the Metropolitan Museum Costume Institute Gala in NYC the following spring.

“They were holding hands and looked very happy and in love,” a witness told Us at the time. “Sienna was smiling ear-to-ear as she and Jude walked up the steps into the Met.”

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Jude Law and Sienna Miller were just snapped arriving back in London after spending their holidays together in Kenya.

Must have been a long flight – cause Jude looks like a bum! I mean that in the nicest way possible.

The happy couple arrived back home following a vacation to Africa. Insiders say that Jude surprised Sienna on Christmas with a gorgeous ring – which he hid inside a grand piano. (I see no ring in these pics.)

A source the Daily Record, “Sienna played the piano as a little girl but hasn’t kept up with lessons. Jude chose a fantastic old grand and had it professionally restored and tuned as a surprise gift for her.”

The insider added, “Sienna wept after opening up the piano lid and discovering a wooden box – made from the same wood as the piano – containing the ring. Jude adores Sienna and would love to make her his wife before next year is out. Family and friends are expecting a save the date card any time soon.”

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Jude Law and Sienna Miller attend the Index on Censorships campaign on free expression in Belarus and the Belarus Free Theatre at The Young Vic.

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Sienna Miller arrives at Heathrow airport coincidentally on the same flight as the famous director Sir Ridley Scott. Perhaps 28-year-old Sienna is looking for some acting work?

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The couple looks like they’ve stepped out of the 1920′s! They look totally cute!  Jude is sporting some facial hair, which he’s grown back for his recurring role in Sherlock Holmes 2, which is filming now.

These are some hot pictures! Jude Law and on-again (rumored) fiance Sienna Miller look hotter than ever! In one picture he’s kissing her naughty bits, they can’t keep their hands off each other! Rawr!

Jude Law is getting a little down time before he begins shooting Sherlock Holmes 2 in October! It was announced this week that Daniel Day Lewis (LOVE HIM!) has signed on to play Holmes’ nemesis Professor Moriarty.

Day-Lewis, who won a best actor Oscar for his work in “There Will Be Blood,” will join Robert Downey, Jr. and Jude Law who respectively reprise their roles as Holmes and Watson in the feature.

At one point, Ritchie considered casting his former “Snatch” thespian Brad Pitt in the part, but his budget couldn’t stretch that far.

U.K.’s The Sun had the scoop.

“Sherlock Holmes,” which was released in December, has minted $517 million at the worldwide box office.

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Jude Law and Sienna Miller – who have broken up MANY times are back together, and hit the red carpet together at last night’s MET Gala. Hopefully this time it sticks, and they stay together forever! They’re cute together, I’ve loved them since “Alfie”.