Actress Katherine Heigl smokes, drinks, and listens to some music during a lunch break from her film, “Five Killers.”  She must have a very patient mother, putting up with all that! Either that, or she’d rather not listen to Katherine Heigl talk!

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Ashton Kutcher and Katherine Heigl look like they’re having a ball while filming a scene for their new film, “Five Killers,” at the Eden Rock Hotel in St. Barts.

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Katherine Heigl’s character Dr. Izzie Stevens revealed she’s dying of cancer on last night’s Grey’s Anatomy — a scoop Us Weekly first reported eight months ago.

On the show, Izzie asked her interns do diagnose “Patient X” — which they don’t know is really her. Lexie (Chyler Leigh) discovers it’s metastatic melanoma — skin cancer — and it’s spread to her brain. (Which explains those hallucinations earlier this season of her dead ex Denny Ducette, played by Jeffrey Dean Morgan.)

“The girl’s pretty much toast,” an intern says. “Survival rate is five percent,” adds another.

In July, Us Weekly reported show higher ups were considering killing Heigl off after she withdrew from Emmy contention because she didn’t feel she was “given the material this season to warrant an Emmy nomination.”

“[Producer] Shonda [Rhimes] and the writers are pissed at her,” the source told Us then, adding that producers were considering giving her a brain tumor. “It’s their way of screwing with her. She won’t know whether she’s going to live or die.”

(”If her character does get a brain tumor, she’ll probably get an Emmy!” a source joked to Us.)

ABC denied Izzie would die, saying, “Katherine is absolutely staying with the show.” Rhimes also said “No” when asked about the plot.

In February, James Pickens Jr. (hospital chief Dr. Richard Webber) confirmed to Usmagazine.com that she’s leaving the show.

“Wherever Katherine goes, I wish her nothing but the best,” he told Us.

“Katherine is ready to move on to the next chapter,” a set source told Us then.

Also out the door, according to Pickens: T.R. Knight. “He just wanted to pursue other career paths,” he told Us at the NAACP Awards luncheon.

Rhimes also claims that’s “not true,” so stay tuned.

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Grey’s Anatomy creator Shonda Rhimes wants to set the record straight: T.R. Knight and Katherine Heigl are not leaving the show.

“That was a very interesting rumor,” Rhimes said Thursday night at the 40th NAACP Image Awards in Los Angeles. “And it’s not true.”

Rhimes was referring to a recent comment in the press attributed to Grey’s castmember James Pickens Jr., in which he was said to be confirming the departure of Heigl and Knight.

“That was absolutely taken out of context,” said Rhimes. “Things happen, and … I think rumors become fact very easily. And you know I don’t like to tell you what’s going to happen on the show — but that is a rumor,” she emphasized.

For his part, Pickens says he meant to wish the pair well in general.

“We’ve been living with these rumors for a long time,” he said before the NAACP’s awards show. “When the question was posed to me, I was more trying to congratulate Katie and T.R. on whatever they were going to do. But yeah, I don’t have any special info about it either way.”

ABC’s Grey’s Anatomy took home three awards, including Chandra Wilson’s win for outstanding actress in a drama series. Wilson said she was looking forward to the show’s upcoming 100th episode — and insisted things were all good on the set.

“We’re laughing at the rumors, as we always do,” Wilson said before the ceremony. “Stories come out, and [there are] these big quotes, and we go, ‘But that’s not exactly what I said.’ So, we’re busy doing our jobs, doing our work.”

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Katherine Heigl and T.R. Knight will soon take off their scrubs for good, their Grey’s Anatomy costar confirms. When Us Weekly asked James Pickens Jr. (a.k.a. Grey’s Dr. Richard Webber) on February 7 if Heigl is leaving the medical drama, he said, “Yes, she is.” And he continued, “Wherever Katherine goes, I wish her nothing but the best.”

Following Heigl, 30, out the door? Her outspoken BFF, Knight, 35. “He’s going too,” Pickens told Us at the NAACP Awards luncheon in Beverly Hills. “He just wanted to pursue other career paths.” “He complains to Katherine all the time,” a set source has said of Knight (with Heigl). “The energy on set will be much better when he’s gone.”

Sources close to the actors concur. “Katherine is ready to move on to the next chapter,” says a set source. And Knight is “not shy about telling people” he wants out of his contract, another insider told Us in December.

But now it seems they’re finally getting their wishes. A source tells Us Knight has had numerous talks with executive producer Shonda Rhimes, and that the “writers are scrambling to find a believable exit for George, one that would leave the door open for him to come back someday.” Both Heigl’s and Knight’s reps had no comment, and ABC and ABC Studios could not confirm the departures.

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