Dr. George O’Malley is dead.

Multiple sources tell EW that T.R. Knight will not be returning to Grey’s Anatomy next season.

Knight’s departure shouldn’t come as too much of a shock…

Not only was George flatlining at the end of the season finale earlier this month, but the 36-year-old actor has reportedly wanted off the hit ABC series for quite some time.

Tension between Knight and show creator Shonda Rhimes has become unbearable for both.

“He hates her, and she hates him,” one source said.

Knight, an original member of the Grey’s cast, was said to have become increasingly frustrated by his character’s lack of storyline and camera face time. In December, he asked to be let out of his contract.

Insiders say Knight has made no secret about George’s demise. No word on any future projects for Knight, but at least now he’s free to pursue other things.

Reps for Knight and ABC declined to comment.

Knight’s best buddy Katherine Heigl is supposedly still waiting to learn her fate with Seattle Grace. Rhimes began contemplating an early death for Dr. Isobel “Izzie” Stevens after Heigl took herself out of the running for last year’s Emmys because, she complained, the writers failed to give her good enough material to work with.

Like George, Izzie was also flatlining at the end of the season finale.

Funny enough, Entertainment Weekly recently reported that Heigl will submit her name for Emmy consideration this year for her work as cancer-stricken Izzie.

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Katherine Heigl has hit another stumbling block on her way to movie stardom. Sources say the actress, whose just-concluded season on ABC’s “Grey’s Anatomy” might have been her last, was dropped from a top-tier ensemble cast in the upcoming romantic comedy “Valentine’s Day” because she demanded an astronomical salary.

The flick, which is scheduled to be released in February 2011, is directed by Garry Marshall and has signed such big names as Julia Roberts, Jennifer Garner, Anne Hathaway, Ashton Kutcher, Shirley MacLaine and Bradley Cooper.

An insider told Page Six, “Producers at New Line originally had Katherine on their casting list. They wanted her for the project, but during the talks, she came back demanding $3 million for the role.”

Our source calls that number “ridiculous” because the movie has “an ensemble cast where there is really no one lead role. Actors are only filming between three and 14 days, and no other actors asked for nearly that amount.”

A rep for Heigl told Page Six, “The story is ludicrous. Early negotiations are a daily occurrence in this business, and just for clarification, Katherine walked away from this project for multiple reasons.” A spokeswoman for New Line had “no comment.”

It’s not the first time Heigl has come across as a diva. In 2007, after “Knocked Up,” she told Vanity Fair the Judd Apatow-directed movie “paints the women as shrews, as humorless and uptight, and it paints the men as lovable, goofy, fun-loving guys. I had a hard time with it on some days.”

She also caused a commotion when she withdrew her name from consideration for last year’s Emmy race, slighting the “Grey’s Anatomy” writers by saying, “I do not feel I was given the material this season to warrant a nomination.” Heigl, whose character was dying of brain cancer, did enter herself in this year’s awards nominations.

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PCN

Actress Katherine Heigl smokes, drinks, and listens to some music during a lunch break from her film, “Five Killers.”  She must have a very patient mother, putting up with all that! Either that, or she’d rather not listen to Katherine Heigl talk!

Bauer Griffin

Ashton Kutcher and Katherine Heigl look like they’re having a ball while filming a scene for their new film, “Five Killers,” at the Eden Rock Hotel in St. Barts.

Bauer Griffin

Katherine Heigl’s character Dr. Izzie Stevens revealed she’s dying of cancer on last night’s Grey’s Anatomy — a scoop Us Weekly first reported eight months ago.

On the show, Izzie asked her interns do diagnose “Patient X” — which they don’t know is really her. Lexie (Chyler Leigh) discovers it’s metastatic melanoma — skin cancer — and it’s spread to her brain. (Which explains those hallucinations earlier this season of her dead ex Denny Ducette, played by Jeffrey Dean Morgan.)

“The girl’s pretty much toast,” an intern says. “Survival rate is five percent,” adds another.

In July, Us Weekly reported show higher ups were considering killing Heigl off after she withdrew from Emmy contention because she didn’t feel she was “given the material this season to warrant an Emmy nomination.”

“[Producer] Shonda [Rhimes] and the writers are pissed at her,” the source told Us then, adding that producers were considering giving her a brain tumor. “It’s their way of screwing with her. She won’t know whether she’s going to live or die.”

(“If her character does get a brain tumor, she’ll probably get an Emmy!” a source joked to Us.)

ABC denied Izzie would die, saying, “Katherine is absolutely staying with the show.” Rhimes also said “No” when asked about the plot.

In February, James Pickens Jr. (hospital chief Dr. Richard Webber) confirmed to Usmagazine.com that she’s leaving the show.

“Wherever Katherine goes, I wish her nothing but the best,” he told Us.

“Katherine is ready to move on to the next chapter,” a set source told Us then.

Also out the door, according to Pickens: T.R. Knight. “He just wanted to pursue other career paths,” he told Us at the NAACP Awards luncheon.

Rhimes also claims that’s “not true,” so stay tuned.

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