George Clooney will be back in his ER scrubs for one final episode of the NBC medical drama that will air March 12.

A show insider tells PEOPLE that Clooney will reunite with Julianna Margulies in a storyline that also features Susan Sarandon, making her ER debut as a grandmother grief-stricken over the sudden death of her grandson.

Although execs of Warner Brothers and NBC have been coy about Clooney’s return, ER’s executive producer John Wells did tell PEOPLE on Wednesday that the March 12 episode will be a memorable one.

“If you’re a fan of ER, you won’t want to miss this one,” said Wells, stopping short of naming the main attraction, Clooney as Dr. Doug Ross.

The episode brings Clooney’s character back to his longtime love Margulies’ nurse Carol Hathaway. Will the star-crossed pair finally get their happy ending?

Wells, who wrote the series’ final episodes, would say only, “I want their story to be very fulfilling in the end.”

Clooney, 47, left ER in 1999 for roles on the big screen. Margulies, 42, who exited the series the following year, recently welcomed her first child Kieran, with husband, attorney Keith Lieberthal.

The show began shooting its two-hour final episode this week. Its series finale will air April 2.

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George Clooney has made an offer few can refuse: He has placed himself up for adoption.

“I always wanted to be adopted, but I couldn’t find anyone,” said the star, speaking at a Newseum event in Washington, D.C., with his father, former Ohio news anchor Nick Clooney, and veteran journalist Bill Small on either side of him.

“Will you adopt me?” George said to Small. “I’m very wealthy. I’ll take care of you.”

Talk of adoption started after Nick Clooney’s observation that his son’s 2005 film, Good Night, and Good Luck, about iconic CBS newsman Edward R. Murrow, is now being shown in journalism schools across the country.

“This film has legs,” said the elder Clooney, who then asked his son for his opinion.

“I don’t care for that,” said the jocular George – prompting Nick to respond: “I never cared for this kid – his sister’s great.”

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George Clooney has agreed to come back to the show that launched his career: ER.

Sources close to the series tell PEOPLE that ER co-creator John Wells has ordered a closed set to keep Clooney’s appearance under wraps.

It’s not known how many episodes will feature Clooney as the show films its final season. Neither NBC nor Warner Bros. reps would comment, nor did Clooney’s publicist.

Clooney, himself, denied reports last March he was returning.

Clooney’s Dr. Doug Ross was last seen on ER in a 2000 cameo walk-through in a remote lake scene with Ross’s ex-Juliana Marguilies.

Clooney is the most famous ER alum and Wells has always wanted him to return for the show’s last season. The 15th season was extended by an extra four episodes by NBC executives last week.

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Actor George Clooney on location in Roswell, New Mexico to shoot ‘Men Who Stare at Goats‘, takes time out from the shoot to play basketball with his driver while dressed as his soldier character Lyn Cassady. As well as wearing army fatigues and the mustache he grew for the role, he bizarrely has kept on the long brown wig he uses for the character, possibly to try not to be spotted by photographers. Obviously having a great time, he can be seen with a huge smile shooting the ball, dribbling and trying on some fancy moves.

Splash

A mustached George Clooney can be seen walking out of his trailer by the set of dark military comedy ‘Men Who Stare At Goats’, in Roswell, New Mexico.
Splash

George Clooney helped raise big bucks for Barack Obama’s presidential campaign by appearing at two intimate events in Geneva, Switzerland, Tuesday night.

Reuters reports that around 170 donors paid $1,000 each to rub shoulders with Clooney and other VIPs at a museum cocktail party, and following that, some 75 contributors paid $10,000 each to dine at “an intimate seated dinner” with the ‘Burn After Reading’ star.

Combined, the two intimate events could raise more than $900,000 for Obama’s campaign, says Reuters.

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WENN

George Clooney is collecting air miles after showing interest in taking the lead in Juno director Jason Reitman’s new film about a businessman obsessed with free trips.

Clooney is in talks to star in Up in the Air, Reitman’s adaptation of Walter Kirn’s novel.

The director has been reworking the script for five years. Upon completion, Clooney was the first actor he showed it to, according to Daily Variety.

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WENN