Christina Applegate has decided to leave her NBC sitcome ‘Up All Night’ after two seasons!

The shocking announcement came this afternoon, and is just weeks after creator Emily Spivey left the series.

“It’s been a great experience working on ‘Up All Night,’ but the show has taken a different creative direction and I decided it was best for me to move on to other endeavors,” Applegate said in a statement. “Working with Lorne Michaels has been a dream come true and I am grateful he brought me into his TV family. I will miss the cast, producers and crew, and wish them the best always.”

There’s no word on how “Up All Night” plans to handle such a major loss, but for now, NBC reportedly plans to move forward on production of the show’s third season.

The network is allegedly looking for potential replacements for Applegate, with Lisa Kudrow said to be under consideration, according to Deadline. It’s not unheard of to swap actors for a major character on a TV series, the two Darrens of “Bewitched” come to mind, but it’s unusual and risky.

Applegate starred as working mom Reagan in the Lorne Michaels-produced family comedy about a couple adjusting to life with a new baby, with Will Arnett as her husband and Maya Rudolph as her bossy bestie.

Applegate’s unexpected exit comes just as the NBC sitcom was in the midst of a major overhaul, changing formats from a single-camera comedy to a multi-camera comedy.

The show has been in a state of constant upheaval since it launched in 2011, including tweaking creative elements and character roles within the show, as well as behind the scenes with a merry-go-round of showrunner turnover — original showrunner Jon Pollack left last May and has been replaced twice since.

I don’t watch the show, so it doesn’t matter much to me. But I think it’s strange that she would leave a sitcom so early on in. Something must have happened!

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