We’ve been waiting for this onscreen pairing for eons: The coolest actor in Hollywood opposite the most beautiful and enigmatic — yes, Johnny Depp and Angelina Jolie will be co-starring in a remake of The Tourist.

Johnny, 46, is in talks to replace Terminator Salvation hunk Sam Worthington, who has pulled out of the male lead role opposite Angelina.

The mom-of-six signed on to replace Charlize Theron who was originally attached to the project.

The movie, which is a remake of a 2005 French spy thriller called Anthony Zimmer, involves a female Interpol agent who uses an American tourist visiting France as bait for a wanted criminal who also happens to be her former lover.

What is it with Angelina, 33, and these international espionage roles? The trailer for her movie Salt was released this week and features all the usual Angie elements: guns, high-speed chases and running from sinister spymasters.

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