Courteney Cox and David Arquette have a challenge for their famous friends: help raise $1 million in two weeks for Epidermolysis Bullosa, a rare skin condition that primarily affects children.

Joining Cox and Arquette in the awareness- and money-raising effort are Jennifer Aniston, Orlando Bloom, Kate Beckinsale, Rashida Jones, James Marsden and Eva Longoria Parker. All will lend their famous faces and financial support to the Epidermolysis Bullosa Medical Research Foundation, where Cox, Arquette and Aniston serve on the honorary advisory board. (Brad Pitt, Gwen Stefani and Gavin Rossdale are also members.)

“EB is very personal to me so I’m happy to be a part of this $1 million challenge,” Cox said in a statement to The Associated Press. “Now is such an important time to put the spotlight on EB and ensure that research can continue at a fast pace.”

Epidermolysis Bullosa is a debilitating genetic disorder that causes the skin to blister and break at the slightest touch. Victims are often covered in burn-like sores that never heal and most don’t live beyond age 30.

WENN