Nip/Tuck’s plastic surgeons relocate to Los Angeles from Miami when the often-outrageous FX drama returns for a fifth season Oct. 23.

Rosie O’Donnell will be back for several episodes as wealthy client Dawn Budge, beginning with the fourth, and Portia de Rossi will play an acupuncturist. But look for fewer guest stars as producers focus on the core family, including Joely Richardson, who returns after a brief absence, reportedly due to a family illness.

The shift to L.A. allows Nip to start fresh, says creator Ryan Murphy: “They ruled Miami as plastic surgeons, and I was very interested in the idea of what happens when you hit 40 and you go from being a big fish in a small pond to the opposite. How do they make it? How do they become top kingmakers again?”

One way is for Sean McNamara (Dylan Walsh) and Christian Troy (Julian McMahon) will work part-time for a fictional show-within-a-show Hearts and Scalpels, which creator Ryan Murphy calls “the worst medical show ever made. It’s run by Oliver Platt, who plays me, and the lead of the show is played by Bradley Cooper, who plays the world’s biggest cad/plastic surgeon,” an even more exaggerated version of Troy. “It’s so bad they hire our guys to be medical consultants,” Murphy says.

The rest of the characters, fairly quickly, also find excuses to move West, where the show was first set when Murphy pitched it to FX. “But we thought it would be a little too on the nose, and I was more interested in doing something darker a little less starlet of the week.” FX has ordered 22 episodes, likely to be split into two seasons, but Murphy, who directed feature Running with Scissors, is game for more. “I would love to do it.”—

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Color me happy!! I can’t wait for the new season!